Funding Opportunities

The National Institute on Aging (NIA) invites R01 applications that propose human studies to better understand the mechanisms underlying compensatory gait, posture, and molecular changes that contribute to slower walking speed and increased metabolic cost of walking. This Notice of Funding Opportunity (NOFO) encourages interdisciplinary collaborations to design integrative approaches that explore interactions among multiple systems (e.g., skeletal, muscle, tendon, somatosensory, and central nervous). This NOFO also encourages innovative approaches such as computational modeling, imaging and sensor technologies, machine learning, and artificial intelligence to disentangle compensatory gait alterations with aging that contribute to increased metabolic cost of walking and fatigue. Areas of interest include: 1) mechanisms and effects of central nervous system changes; 2) neuromuscular changes; 3) skeletal muscle bioenergetics; 4) computational modeling and simulation; and 5) changes in tissue structure and function (e.g., muscle-tendon complex, extracellular matrix)).