Funding Opportunities

The Patient-Centered Outcomes Research Institute (PCORI) issues the Phased Large Awards for Comparative Effectiveness Research (PLACER) PCORI Funding Announcement (PFA) to fund high-quality patient-centered comparative clinical effectiveness research (CER) projects that will address critical decisions faced by patients, caregivers and the broader healthcare community and for which there is insufficient evidence. Investigators must propose an individual-level or cluster-randomized controlled trial of significant scale and scope for this PFA. The proposed trial should address a critical decisional dilemma that requires important new evidence about the comparative clinical effectiveness of available interventions. Proposed studies should compare interventions that already have robust evidence of efficacy and are in current use. If efficacy is not well established, then widespread use must be documented. Clinical interventions (such as medications, diagnostic tests or procedures) and delivery system interventions (such as workforce, technologies and healthcare service delivery designs) are appropriate for these studies.