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New Approaches for Measuring Brain Changes Across Longer Timespans (R21 Clinical Trial Optional) - PAR-25-272

Funder
National Institutes of Health
LOI Required
No
Application Deadline
Maximum Project Duration
2 years
Research Focus Areas
Neurobiology/Neuroscience
Genomics
Population Focus
Older Adults
Research Methods
Randomized Control Trials (RCT)
Neural Networks
Description
The purpose of this funding opportunity is to encourage multidisciplinary investigators to develop exploratory, highly novel new approaches, or innovative applications of existing approaches, to measure brain activity, connectivity, genomics, or other aspects across the age spectrum of neurodevelopment. The overarching goal is to extend our understanding of brain development and aging, including studies of the neurodevelopmental origins of later health and disease, by improving repeated measures across longer epochs of the lifespan to better predict outcomes at later ages. Research can include healthy human participants of any age; specific clinical groups such those with cognitive, motor, or affective regulation challenges; and/or animal research on these domains of function. The studies can focus on longitudinal neuroanatomical or functional changes at any level, including genetics/genomics, single cells, connectomics, neural population activity patterns, and others. This funding opportunity is intended to encourage technological and conceptual innovation through this high risk, high reward funding mechanism to develop highly innovative ideas that either lack preliminary data or need additional preliminary data.