Improving Methods for Conducting Patient-Centered Comparative Clinical Effectiveness Research PCORI Funding Announcement - Cycle 3 2025
Funder
Patient-Centered Outcomes Research Institute
LOI Deadline
LOI Required
Yes
Application Deadline
Maximum Project Duration
3 years
Research Focus Areas
New
Clinical
Training (e.g. community providers, staff, faculty, peers)
Delivery and Utilization of Care
Workplace Mental Health/Burnout
Access to Care
Learning Disabilities/Developmental Delays
Pain
Medical Comorbidities
Artificial Intelligence/Machine Learning
Research Methods
Artificial Intelligence/Machine Learning
Description
The Patient-Centered Outcomes Research Institute (PCORI) intends to release an Improving Methods for Conducting Patient-Centered Comparative Clinical Effectiveness Research (Methods) PCORI Funding Announcement (PFA) on Aug. 12, 2025, seeking to fund studies that address high-impact methodological gaps in patient-centered comparative clinical effectiveness research (CER). This preannouncement is provided to allow potential applicants additional time to identify collaborators; obtain patient and stakeholder input on potential studies; and develop responsive, high-quality proposals.
PCORI seeks to fund projects that address important methodological gaps and lead to improvements in the strength and quality of evidence generated by CER studies.
For all three funding cycles of the 2025 Methods PFA, PCORI has identified the following areas as program priorities:
- Methods To Improve the Use of Artificial Intelligence (AI) and Machine Learning (ML) in CER.
- Methods To Improve Study Design.
- Methods To Support Data Research Networks.
- Methods Related to Ethical and Human Subjects Protections Issues in CER.