Funding Opportunities

More effective interventions are needed across the continuum of care, from prevention and early intervention to screening and diagnosis and, where indicated, treatment. This PFA calls for system-, community- and individual-level interventions that improve mental and behavioral health conditions. Approaches leading to improved mental and behavioral health outcomes for under-researched and underserved populations are of interest. Appropriate settings for intervention delivery include, but are not limited to, outpatient clinics, in-patient settings, primary care practices, community-based organizations and schools. This opportunity aims to fund studies comparing two or more approaches for prevention, diagnosis, treatment or care delivery related to mental and behavioral health conditions. Studies should address a critical clinical or care delivery problem. Proposed comparators must have well documented evidence of efficacy and/or widespread use, as demonstrated by prior research, systematic reviews and/or clinical guidelines. Studies should include evidence-based, impactful, patient-centered outcomes as indicated by patients, families and caregivers (particularly those with lived experience) from the population of interest, as well as relevant members of the broader health and healthcare community. At least one primary outcome should be a mental health outcome. Clinically meaningful outcomes (e.g., no longer meeting diagnostic criteria or using patient-centered minimum clinically important differences) are encouraged, as well as longer-term follow-up (e.g., 12 months) that allows for the measurement of recovery from and recurrence of mental health symptoms.