Funding Opportunities

The Patient-Centered Outcomes Research Institute (PCORI) intends to issue an Improving Methods for Conducting Patient-Centered Comparative Clinical Effectiveness Research (Methods) PCORI Funding Announcement (PFA) on April 1, 2026, seeking to fund studies that address high-impact methodological gaps in patient-centered comparative clinical effectiveness research (CER). This preannouncement provides potential applicants additional time to identify collaborators; obtain patient and stakeholder input on potential studies; and develop responsive, high-quality applications. PCORI seeks to fund projects that address important methodological gaps and lead to improvements in the strength and quality of evidence generated by CER studies. For the Cycle 2 2026 Methods PFA, PCORI has identified the following areas as program priorities: • Methods To Support the Use of Patient-Centered Measurement in Patient-Centered CER (NEW) • Methods To Support the Use of Real-World Data (RWD) in Multi-Site Patient-Centered CER (formerly Methods To Support Data Research Networks) • Methods To Improve the Use of Artificial Intelligence (AI) and Machine Learning (ML) in Patient-Centered CER • Methods To Improve Study Design in Patient-Centered CER This funding announcement will accept applications with direct costs of up to $750,000 and up to three years in duration.